0:00:05 | well as more faster you know the past years |
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0:00:14 | l o u r l |
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0:00:22 | when i work will focus on there are seven years |
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0:00:37 | that is expressed by sensing |
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0:00:44 | but also for you want to know image at no cost for themselves |
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0:00:55 | which was a perceptual by |
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0:01:01 | but as well as a step by step by l one |
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0:01:16 | well |
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0:01:22 | this |
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0:01:24 | one thing one |
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0:01:29 | why this is used for |
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0:01:35 | this is not except for very often |
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0:01:47 | on the cell surface membrane we have identified a novel signalling platform that is critical |
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0:01:52 | for the activation of the like also later time as in kindest receptors like the |
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0:01:55 | nerve grow factor track a |
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0:01:58 | the signalling platform consists of a tripartite alliance made up on them aluminium in today's |
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0:02:02 | one also known as new once either days matrix motel approach in is nine also |
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0:02:06 | known as i'm m p nine and g protein coupled receptors |
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0:02:10 | new one which is part of the multi in them at a complex a beta |
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0:02:13 | collect a side project approaching if that's and a and the alaskan binding protein forms |
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0:02:17 | a complex with the receptor at the apple domain with m p nine and the |
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0:02:20 | g protein coupled receptor |
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0:02:23 | the like and binds to the receptor which initiates a confirmation of change to induce |
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0:02:27 | the g p c r signalling process tethered to and m p nine via g |
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0:02:31 | alpha one proteins activated g protein subsequently activate and m p nine |
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0:02:37 | it is the last integrating activity of mlp nine the fits well within this novel |
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0:02:41 | signalling paradigm a time synchronous receptor activation |
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0:02:45 | direct removal of the last in binding protein from the multi and semantically once other |
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0:02:49 | days complex by activated m p nine is proposed to induce me want |
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0:02:54 | activated new one requires protective protein concepts and eighty performance and the maddox activity |
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0:03:00 | activate a new one already bound to the after domain other sceptre specifically removes the |
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0:03:05 | l for two three c l residues of the receptor to facilitate die memorisation |
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0:03:09 | this receptor die memorisation is essential for time a synchronous receptor fast relation and subsequent |
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0:03:14 | cellular signaling and activation |
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0:03:18 | exactly |
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0:03:23 | what are quite well as well |
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0:03:30 | show that are only used once the other |
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0:03:37 | that is useful for instance |
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0:03:43 | every once the l e o is that suggests that a strong |
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0:03:53 | or |
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0:03:54 | it seems that it is possible to l r |
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0:04:02 | this is this right which i once the l g i |
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0:04:10 | reported here last row one |
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0:04:19 | in this one once you know |
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0:04:24 | if i z |
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0:04:28 | and i is a bit later |
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0:04:30 | it is not clear that |
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0:04:35 | where you're at this can use why l s e c one on the other |
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0:04:48 | day |
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0:04:51 | yes |
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0:04:54 | one is that are expressed |
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0:05:02 | these results suggest that there is only one once you there |
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0:05:14 | and you are able to translate small g or c |
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0:05:22 | the parents that the literature that the speculation for social role |
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0:05:33 | you hear the speculation original form |
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0:05:38 | first of all |
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0:05:44 | one of the state i e |
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0:05:51 | in the right number here there that's |
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0:05:59 | okay over six hundred eighteen hundred i will show or more |
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0:06:13 | one or two or more syllables which we will see that there is like to |
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0:06:22 | hear what which may be different here |
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0:06:30 | which are you want to see that |
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0:06:42 | moreover there are multiple or more natural |
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0:06:49 | given the large numbers are we assume that there is like |
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0:07:02 | it is easily draw our work is that why we have so far |
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0:07:17 | future research for this work we should |
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0:07:23 | this one h so maybe |
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0:07:29 | okay |
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