0:00:05well as more faster you know the past years
0:00:14l o u r l
0:00:22when i work will focus on there are seven years
0:00:37that is expressed by sensing
0:00:44but also for you want to know image at no cost for themselves
0:00:55which was a perceptual by
0:01:01but as well as a step by step by l one
0:01:16well
0:01:22this
0:01:24one thing one
0:01:29why this is used for
0:01:35this is not except for very often
0:01:47on the cell surface membrane we have identified a novel signalling platform that is critical
0:01:52for the activation of the like also later time as in kindest receptors like the
0:01:55nerve grow factor track a
0:01:58the signalling platform consists of a tripartite alliance made up on them aluminium in today's
0:02:02one also known as new once either days matrix motel approach in is nine also
0:02:06known as i'm m p nine and g protein coupled receptors
0:02:10new one which is part of the multi in them at a complex a beta
0:02:13collect a side project approaching if that's and a and the alaskan binding protein forms
0:02:17a complex with the receptor at the apple domain with m p nine and the
0:02:20g protein coupled receptor
0:02:23the like and binds to the receptor which initiates a confirmation of change to induce
0:02:27the g p c r signalling process tethered to and m p nine via g
0:02:31alpha one proteins activated g protein subsequently activate and m p nine
0:02:37it is the last integrating activity of mlp nine the fits well within this novel
0:02:41signalling paradigm a time synchronous receptor activation
0:02:45direct removal of the last in binding protein from the multi and semantically once other
0:02:49days complex by activated m p nine is proposed to induce me want
0:02:54activated new one requires protective protein concepts and eighty performance and the maddox activity
0:03:00activate a new one already bound to the after domain other sceptre specifically removes the
0:03:05l for two three c l residues of the receptor to facilitate die memorisation
0:03:09this receptor die memorisation is essential for time a synchronous receptor fast relation and subsequent
0:03:14cellular signaling and activation
0:03:18exactly
0:03:23what are quite well as well
0:03:30show that are only used once the other
0:03:37that is useful for instance
0:03:43every once the l e o is that suggests that a strong
0:03:53or
0:03:54it seems that it is possible to l r
0:04:02this is this right which i once the l g i
0:04:10reported here last row one
0:04:19in this one once you know
0:04:24if i z
0:04:28and i is a bit later
0:04:30it is not clear that
0:04:35where you're at this can use why l s e c one on the other
0:04:48day
0:04:51yes
0:04:54one is that are expressed
0:05:02these results suggest that there is only one once you there
0:05:14and you are able to translate small g or c
0:05:22the parents that the literature that the speculation for social role
0:05:33you hear the speculation original form
0:05:38first of all
0:05:44one of the state i e
0:05:51in the right number here there that's
0:05:59okay over six hundred eighteen hundred i will show or more
0:06:13one or two or more syllables which we will see that there is like to
0:06:22hear what which may be different here
0:06:30which are you want to see that
0:06:42moreover there are multiple or more natural
0:06:49given the large numbers are we assume that there is like
0:07:02it is easily draw our work is that why we have so far
0:07:17future research for this work we should
0:07:23this one h so maybe
0:07:29okay