We Share Science

Video abstract of review paper 'A novel G-protein-coupled receptor-signaling platform and its targeted translation in human disease' published in the open access journal Research and Reports in Biochemistry by Abdulkhalek S, Hrynyk M, Szewczuk MR. Abstract: Molecular-targeted G-protein-coupled receptor (GPCR) signaling in human disease has become an important area of scientific and medical research. The interactions between GPCRs with their large number of different G-protein subunits and the large number of glycosylated receptors involved in human diseases are quite diverse. One GPCR is capable of interacting with more than one G protein to initiate multifunctional signaling. However, the activation of a number of GPCRs does not always lead to a direct effect alone on a particular signaling pathway, but rather to an amplification of the response produced by a separate circumstantial signal within the cell. This cross talk among different GPCR transduction signals is a focus of intense research. In this review, evidence exposing the invisible link connecting ligand-binding and receptor activation to a novel GPCR-signaling platform will be reviewed in relation to human disease. Read the full paper here: http://www.dovepress.com/a-novel-g-protein-coupled-receptor-signaling-platform-and-its-targeted-peer-reviewed-article