hello i'm not to james the shapiro professor of surgery madison and surgical oncology the
universe developers from canada research chair
i'm delighted provide this video update the companies are the chapter on a cell transplantation
the features there if the type one diabetes
of these islands the refusing to patient to patient so they vary in size between
fifty and hundred fifty microns that they are derived
from human organ donors the same organ donors to provide heart lungs and lippus the
transplantation and the stained here with that i called a that is on the stains
a zinc
no this is a video provided to me kind of i don't similar recording in
miami
and you can see here that he's a human pancreas that is being digested
it's first kind related to deliver collagen is into the pan correct up system
i'm not the kind relation of the pancreas and we distend the enzymes tropical and
then chop have been to pieces and then place the pancreas into what's called the
recording chamber committed to develop this in the late nineteen eighties and is become these
standard way the only way infected to isolate large numbers if you monotonous f
the transplantation here the pangs been confused and then set like to placed into a
chamber numbers we want to the chamber
and then the chamber here is shown
so the transcriber couples we have i is very straightforward so we inject a local
anaesthetic in the side and the others refused in the letter
into the portal vein runs up and for living he's a for underground we see
the cat the sitting in the maplewood then it simply trip in the cells into
a while measuring the pressure
and including the track at the end thanks to seventy seven are transparent recalled here
the safest transplant by far done in the right way and the trackers that is
adequately placed at the end of the procedure
now with the other transpire activity that has been a large number of transpose before
that there are thirty also active sites internationally time so that the drop in activity
in the last a few years that because many the size depending dependent upon research
funding
but you can see in the universe up it will be carried out sixty six
out a transparent set last year and we have patience to follow for fourteen years
in fact to the first patients a still completed for events in the about fourteen
half years now after the transplants
we found early on that the we lost some function of the others so that
about three to four years most patients data to go back on instant so we've
been working on plugging the holes since to improve function
by removing factors that lead to any damage violet such as the donor and reprocessing
injury high proxy hypothesis information
would be looking also to one that minimizing like graph lost by a controlling the
cute in colour rejection
all team unity metabolic stress and we've been using onto the map induction of patience
to facilitate this process and now very standard you mean the suppression with the problem
ssl set
we know that many the that so that we transparent are inadequate and are require
further optimisation
another only six sensors in the will that have over a half the patients instant
free at about five years including sends the minnesota ourselves and happen to where a
chipset impatience to remain is infinite seven years and several the sciences one including san
francisco university of illinois leland the geneva gradual network
and these results are improving all the time so this jack chapter will discuss in
detail the outcomes in the future opportunities for improving on a cell transplantation to make
it more available the patience a type one diabetes that we enjoy reading it thank
you