0:00:01hello i'm not to james the shapiro professor of surgery madison and surgical oncology the
0:00:06universe developers from canada research chair
0:00:09i'm delighted provide this video update the companies are the chapter on a cell transplantation
0:00:14the features there if the type one diabetes
0:00:17of these islands the refusing to patient to patient so they vary in size between
0:00:21fifty and hundred fifty microns that they are derived
0:00:24from human organ donors the same organ donors to provide heart lungs and lippus the
0:00:29transplantation and the stained here with that i called a that is on the stains
0:00:33a zinc
0:00:34no this is a video provided to me kind of i don't similar recording in
0:00:38miami
0:00:39and you can see here that he's a human pancreas that is being digested
0:00:44it's first kind related to deliver collagen is into the pan correct up system
0:00:49i'm not the kind relation of the pancreas and we distend the enzymes tropical and
0:00:53then chop have been to pieces and then place the pancreas into what's called the
0:00:57recording chamber committed to develop this in the late nineteen eighties and is become these
0:01:01standard way the only way infected to isolate large numbers if you monotonous f
0:01:06the transplantation here the pangs been confused and then set like to placed into a
0:01:10chamber numbers we want to the chamber
0:01:13and then the chamber here is shown
0:01:16so the transcriber couples we have i is very straightforward so we inject a local
0:01:21anaesthetic in the side and the others refused in the letter
0:01:24into the portal vein runs up and for living he's a for underground we see
0:01:28the cat the sitting in the maplewood then it simply trip in the cells into
0:01:31a while measuring the pressure
0:01:33and including the track at the end thanks to seventy seven are transparent recalled here
0:01:37the safest transplant by far done in the right way and the trackers that is
0:01:41adequately placed at the end of the procedure
0:01:44now with the other transpire activity that has been a large number of transpose before
0:01:48that there are thirty also active sites internationally time so that the drop in activity
0:01:52in the last a few years that because many the size depending dependent upon research
0:01:56funding
0:01:58but you can see in the universe up it will be carried out sixty six
0:02:00out a transparent set last year and we have patience to follow for fourteen years
0:02:04in fact to the first patients a still completed for events in the about fourteen
0:02:09half years now after the transplants
0:02:12we found early on that the we lost some function of the others so that
0:02:15about three to four years most patients data to go back on instant so we've
0:02:20been working on plugging the holes since to improve function
0:02:24by removing factors that lead to any damage violet such as the donor and reprocessing
0:02:29injury high proxy hypothesis information
0:02:32would be looking also to one that minimizing like graph lost by a controlling the
0:02:36cute in colour rejection
0:02:38all team unity metabolic stress and we've been using onto the map induction of patience
0:02:42to facilitate this process and now very standard you mean the suppression with the problem
0:02:46ssl set
0:02:48we know that many the that so that we transparent are inadequate and are require
0:02:53further optimisation
0:02:54another only six sensors in the will that have over a half the patients instant
0:02:59free at about five years including sends the minnesota ourselves and happen to where a
0:03:04chipset impatience to remain is infinite seven years and several the sciences one including san
0:03:08francisco university of illinois leland the geneva gradual network
0:03:14and these results are improving all the time so this jack chapter will discuss in
0:03:19detail the outcomes in the future opportunities for improving on a cell transplantation to make
0:03:24it more available the patience a type one diabetes that we enjoy reading it thank
0:03:28you