0:00:02 | someone even stopped a single of energy and i'm a consultant and strict medicine at |
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0:00:06 | imperial college okay and it just stressed |
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0:00:09 | so this paper a the purpose was to provide an updating to the benefits of |
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0:00:15 | stem cell therapy instruments and |
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0:00:18 | in terms of pre clinical evidence is very good evidence for benefits of stem cells |
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0:00:23 | in straight models but in terms of translating that to the bedside that's very much |
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0:00:29 | in its infancy stroke is a major calls mortality and morbidity across the world we |
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0:00:35 | know that it is the seconds commonest single coils of that |
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0:00:38 | worldwide and also be common discourse about of disability across the globe |
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0:00:44 | so there's a real and pressing need to new treatments in the field of straight |
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0:00:48 | medicine and perhaps regenerative strategy so just stem cell therapy and number of different theories |
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0:00:55 | of been proposed which we discussed in the pay |
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0:00:58 | this review article of written with my colleagues who have also worked on with the |
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0:01:03 | clinical trial that were involved in and that is deborah williams and german chance when |
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0:01:08 | s and i b |
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0:01:10 | the commonest trees and this house themselves work is that you but a stem cell |
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0:01:16 | into the damaged area and then a tree grows that a lot of that to |
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0:01:19 | converge several conditions in terms of the brain and stroke |
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0:01:24 | and there's very little evidence that that's house themselves what that they go in region |
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0:01:28 | right resentment evidence for top lots of different types of stem cells |
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0:01:33 | given to a stress induced straight models so animals at different times after straight and |
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0:01:42 | given to animals by different methods of delivery for example direct implementation interest ripple implantation |
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0:01:48 | given |
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0:01:49 | systematically such as intravenously control theory some of these different things have been shown to |
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0:01:54 | work in different trials |
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0:01:57 | the challenge now is translating that's |
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0:02:00 | to clinical arena and deciding which is the best type system so you when should |
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0:02:06 | be can be giving it to locations of just wrote |
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0:02:09 | how should be given to patients amongst a number of all this controls which we |
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0:02:14 | discuss in the by already there are a number phase one phase two trolls which |
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0:02:18 | have been completed or gabbing same in this paper we review and one of the |
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0:02:23 | completed trials which been published and also give a summary of the ongoing trials |
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0:02:29 | so |
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0:02:30 | that is definitely a moving the right direction |
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0:02:34 | but arts has been mentioned in the paper there are lots of challenges lots of |
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0:02:38 | unanswered questions which need to be looked at in more detail and if we're going |
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0:02:42 | to take this for which the key to success will be more coordinated research and |
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0:02:48 | paying attention to expert opinion |
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0:02:50 | from people that in this field as has been published in for example steps recommendations |
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0:02:57 | which we mention in a paper |
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