0:00:03professor presentable and one of the authors about like a reporting on the in vitro
0:00:08an in vivo evaluation oversampling you'll thing to know why for formulation
0:00:14on the professor at the school of pharmacy of cushion university in western australia
0:00:20the first recorded use of something you'll administration of a drawn was that of cluster
0:00:25i'll try not right uniting seventeen are
0:00:28although that method of delivery was remarkably effective until recently there has been little for
0:00:34the development of the use of something you'll delivery for systemic grog action
0:00:40just something you'll and buckle words
0:00:42that often being linked in drug delivery however there are differences between the nature of
0:00:48the apathy leo
0:00:50main brian's involved in drug absorption
0:00:53just something related celia contains fuel cell lie as compared with that of the buckle
0:00:58because a rendering it more permeable
0:01:02hence a sampling over it is better suited to treatments requiring rapid absorption
0:01:08there is also a greater likelihood of partials following of the all county
0:01:13with buckle delivery
0:01:16sampling you'll administration is very simply carried out for all age groups and avoids than
0:01:22they just wallet habits okay pedals which can be problematic for some actions
0:01:28drug absorbed from the sampling go pouches and central surface of the top
0:01:33trying to into the job you love i in and therefore is delivered directly to
0:01:38the systemic circulation
0:01:42group has been involved for some he is in the development of a sampling your
0:01:46product that will give rapid absorption a suitable drugs for immediate action
0:01:52one drug we have worked with this thing to know which has excellent physical chemical
0:01:57characteristics for some lingual absorption
0:02:01the lecture is prepared by freeze drying and included sodium cup boxing makefile serialise and
0:02:07the bottle a gown as matrix for
0:02:10and man at all and ricean to why the freeze drying process
0:02:15absence of characteristic peaks of functional in the x tried effective gram
0:02:20pointed to this process achieving i'm of isolation of the drug during the freeze drying
0:02:26process
0:02:27the way fisheye very rapid disintegration
0:02:30all less than three minutes
0:02:33it is evidence that when a wife or is added to you can see the
0:02:37wreck the disintegration of the wife
0:02:39importantly approximately ninety percent of internal this all within one minute
0:02:47a pilot study in patients evaluating pain relief following the hanukkah logical surgery involves something
0:02:55you'll administration of the wife which i rapid absorption the functional with the first detectable
0:03:01placement levels at three and half minutes
0:03:05the overall while probability was fifty three percent
0:03:09a study we have published elsewhere it using the sign bits each for been him
0:03:14involuntary is headed by availability you know seventy i to sing
0:03:19do you about tighter idea could when the patient something you'll area had been pretty
0:03:23weighted with three males of war to try to administration
0:03:28actions his mouth was not pretty weighted show a much lower initial absorption of the
0:03:33drug
0:03:34maybe actions might have a dry masked by a tree
0:03:38or course by treatment without the drugs
0:03:41it is important that the masses pretty weighted before sampling you'll administration of any occur