0:00:01well
0:00:02my name is jennifer occur in geneva
0:00:05and i met coauthor of the manuscript entitled pell appeared on comedy versus your spare
0:00:11down long acting intractable
0:00:13and subjects with schizophrenia
0:00:15recently treated with oral we're spare down
0:00:17or other or lms the context
0:00:20schizophrenia i faxed just over one percent of the adult population with an estimated fifty
0:00:26one million suffer worldwide
0:00:30all those symptoms can be treated of actively with in a psychotic medication
0:00:34for adherence to prescribe treatment is a well recognise problem
0:00:40for adherence is associated with clinical
0:00:43and functional deterioration
0:00:45an increased risk a relapse
0:00:47we have scroll addition and suicidal behaviour
0:00:52simplified and i psychotic medication regimens
0:00:55such as long acting intractable formulations
0:00:58may be helpful
0:00:59in improving adherence
0:01:02patients given oral once daily dosing must remember to take their medication three hundred and
0:01:08sixty five times a year
0:01:10with a long acting intractable formulation
0:01:13this is reduced to twenty six times yearly for biweekly dosing and twelve times yearly
0:01:19for monthly dosing
0:01:21also with marketing intractable and as the context
0:01:25health care providers can be certain of their patient's adherence and resources are not wasted
0:01:31on discarded or forgotten medication
0:01:34it is unclear whether certain subpopulations within the schizophrenia spectrum
0:01:39would be likely to benefit from these potential advantages
0:01:43in particular because of the similarity between the molecules
0:01:48one might question whether person to have failed treatment with or were spared own
0:01:53we show a good quote corresponds to long acting pell occurred on comedy
0:01:57or long acting wrist area down
0:02:00and this article we describe a post hoc subgroup analysis of a thirteen week randomised
0:02:06double one trial
0:02:08undertaken to address this question
0:02:11the original trial evaluated response to treatment with long acting intractable help her don't comedy
0:02:17or long acting inject upon which their down
0:02:20in subjects with schizophrenia who were experiencing clinically significant symptoms
0:02:26despite recent treatment with oral pinnits the context
0:02:30efficacy was measured by noting improvements in pans total score
0:02:35p and factor scores
0:02:37and c g i severity scale score a total of seven hundred and forty seven
0:02:43subjects from the original study were included in this subgroup analysis
0:02:48during the two weeks before the start of the double blind study medication two hundred
0:02:54and thirty three subjects had received or over spare don't
0:02:58four hundred and two had received another oral in a psychotic
0:03:02and one hundred and twelve had not received any in a psychotic medication
0:03:07at the end of thirteen weeks of treatment
0:03:10statistically significant improvements from baseline and point
0:03:14where seen in all f sixty measures
0:03:16within each group for both pell appeared on comedy
0:03:20under stared on long acting injection
0:03:23regardless of previous oral in a psychotic treatment
0:03:27you can see from the highlighted data
0:03:29that a change from base fine for all parameters appeared similar across groups
0:03:35their responses were statistically significant
0:03:38all comparisons within each group had a p-value less than or equal to zero point
0:03:44zero two
0:03:48similarly
0:03:49functioning improved significantly for subjects within each group
0:03:53for about how they are not comedy and they were spared on long acting injection
0:03:58personal and social performance scale
0:04:00or psp
0:04:02scores significantly improved from baselines and point among all previous treatment subgroups
0:04:08this speaker shows that the distribution of categorical p s p scale scores
0:04:14improved across all groups from baselines and point
0:04:19from two to sixty one percent of subjects across the subgroups analyzed experience one or
0:04:25more treatment immersion adverse of that
0:04:29common adverse events or power pair don't comedy it subjects
0:04:32where insomnia
0:04:34seven point one to twelve point six percent
0:04:37had a week six point three to nine percent
0:04:40an injection site pain
0:04:42three to ten point seven percent
0:04:44you respective of higher order we're stared on status
0:04:48common adverse events for all over spared on long acting injections subjects were insomnia
0:04:54five point sixty eight point four percent and headache
0:04:57five point forty nine point four percent
0:05:00in summary
0:05:01our analysis suggests that treatment with how appeared on comedy or were spared on long
0:05:06acting injection can be effective in patients
0:05:09regardless of previous oral in a psychotic treatment
0:05:13for patients who had previously received or over spare don't only
0:05:18the difference in the formulation was the mean change in the intervention
0:05:22as the molecules oliver remain the same or similar
0:05:27these data support the contribution
0:05:29of a long acting formulation
0:05:32to improving treatment response
0:05:34and suggest that not adherence may be a significant contributor to in an adequate efficacy
0:05:41oral formulations impatience with schizophrenia
0:05:45thank you for your interest
0:05:46and we hope you have found our analysis useful
0:05:49in the management of you are patients who are receiving in a psychotic each utterance