my name is rubberness and i met him at holidays at the mayo clinic
and it's my pleasure the present this video abstract
and the manuscript written by rabbit emmanuel holly guy or and myself and voxal in
the as an emerging therapy for model fibrosis
model fibrosis is a chronic cologne all my lapel effort of ne of class
it is a disease that affects individuals with wanna make early symptoms
potential for site opinions
the potential for progression look you'd milo talking and sadly frequently premature death from the
onus
in two thousand five it was of the discovery of achieve imitation in the model
parallel for the veneer parzen half the genesis
that of the jack to be six and seven f mutation
the discovery that annotation lead to a rabbit effort to develop it is that were
inhibitory of the jacks that pathway
and hitters object one inject to have now been developed in tested in individuals with
model fibrosis
and the manuscript we discuss at least in development
in early development eight in such as an s zero one eight o y two
seventy four five four
agents in face to face three testing set just as they are three o two
five or three see what you three eight seven and procreate in
these agents have demonstrated the ability
for these inhibitors of jack to help to reduce plan a magazine these individuals and
improve symptoms it is either maybe some variable benefits for anaemia related with the disease
as demonstrated by c y t three eight seven and potentially poch written
finally we going to the greatest detail in terms of the data for rock celine
right solution of is now prove in the united states from the f d a
as well as in europe in other countries
based on the data from two randomized phase three trials
these two trials called the comfort studies compared rocks a minute with either perceivable in
the north american trial and versus best alternative therapy in the europeans trial
these trials demonstrated that compared to these control on the rocks and then the
was significantly superior for the reduction of smell mightily
improving symptoms related with the disease improving quality of life
and now improvement in survival compared to those control are
in the manuscript we going to a discussion of the use approximate and then we
talk about upcoming combination clinical trials
as well as new drugs in development
we also try to portray the futures keep up there before model fibrosis
thanks to all of these scientific energy but into the disease particle e over these
last five years is a much brighter future for patients with modified process
thank