| 0:00:00 | and |
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| 0:00:05 | stroke remains a common cause of morbidity and mortality within the general population |
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| 0:00:11 | each year nearly eight hundred thousand new are required stroke events occur and account for |
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| 0:00:16 | approximately one out of every eighteen das and united states |
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| 0:00:20 | in addition to traditional cardiovascular risk factors and nontraditional factor that may contribute to stroke |
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| 0:00:26 | risk is the use of non straight all in time phonatory drugs also known as |
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| 0:00:31 | and sets |
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| 0:00:32 | although much publicity has focused on the risk of adverse cardiac events |
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| 0:00:36 | stroke compromises another important subset of risk |
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| 0:00:39 | and this review we discuss the evidence with regard to an association between selective and |
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| 0:00:44 | non selective and sets and stroke risk |
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| 0:00:47 | potential mechanisms for an association are shown in table one these agents affect the balance |
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| 0:00:52 | of various process acquaintance drum boxing process likely in the regulation of the cycle oxygen |
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| 0:00:58 | e sands i'm with downstream effects shown in figure one |
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| 0:01:02 | much of the initial suggestions of an association between and said in cardiovascular risk came |
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| 0:01:07 | from perspective studies assessing easy agents into menstrual in cancer prevention |
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| 0:01:13 | within these studies there was a suggestion of an association between and said and stroke |
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| 0:01:18 | all the results were not consistent |
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| 0:01:21 | much of the subsequent data demonstrating hind risk of stroke events |
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| 0:01:26 | we're based on observational studies |
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| 0:01:28 | and the relevant risk estimates from these studies are listed in table two |
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| 0:01:33 | within these limited analyses observational studies have not found a different role risk with either |
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| 0:01:39 | is schema or hammer abject stroke |
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| 0:01:42 | elderly patients does or particular mention as chronic use of and sets increases with each |
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| 0:01:47 | but then estimated up to forty percent of individuals over age sixty five years using |
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| 0:01:52 | either over the counter are prescribed and sets |
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| 0:01:55 | due to the increase risk adverse gastrointestinal and cardiovascular side effects |
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| 0:02:00 | the use of and said in this population has been of ice to get |
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| 0:02:04 | additionally hypotensive effects of and sets may be particularly prominent in the elderly |
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| 0:02:10 | the current evidence does not support an association between and set used in stroke risk |
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| 0:02:14 | in the elderly however and said you should be avoided whenever possible in favour of |
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| 0:02:19 | non and said you know jeez |
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| 0:02:22 | initial evidence from perspective trials demonstrating increase grist |
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| 0:02:26 | of adverse how gregor basket or events |
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| 0:02:29 | what to the withdrawal of several selective cox two inhibitors |
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| 0:02:32 | although the evidence from these initial perspective trials suggest it is so she shouldn't with |
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| 0:02:37 | coronary ski make advance |
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| 0:02:39 | the evidence for a link between and said to instruct events remains a source of |
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| 0:02:43 | debate |
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| 0:02:44 | as the evidence here has been presented no definitive recommendations can be made regarding the |
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| 0:02:49 | use of and sets with respect to stroke risk |
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| 0:02:53 | however alternative energies it should be considered whenever possible particularly elderly and if and that's |
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| 0:02:59 | are used there were duration should be a short as possible |
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| 0:03:03 | future study should focus on further assessing the risk of specific vascular beds |
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| 0:03:07 | such as the risk of stroke with specific and sets |
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| 0:03:10 | but selective and on selective |
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| 0:03:13 | thank you |
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| 0:03:15 | and |
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| 0:03:20 | they |
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