0:00:04i'm not to come on one of the authors of this manuscript oxygen resuscitation and
0:00:09also data stress biomarkers in premature infants
0:00:13thus this additional premature infants less than thirty two weeks gestation a one request an
0:00:19illustration of oxygen
0:00:21however and a oxygen defence mechanisms against high levels of oxygen explosive audio's latent gestation
0:00:28ids infants are not ready to face the challenge of oxygen stress related by products
0:00:35leading to brown carpentry displays
0:00:38thus this additional premature inference with reduced oxygen concentration result in lower system adopted in
0:00:45stressed and lower incidence of bp d in the current study we tested the hypothesis
0:00:50that limiting oxygen x files are at resuscitation in premature inference would decrease system across
0:00:57a day to stress
0:00:58as assessed by right use good that i don't to also doesn't apply a ratio
0:01:03plasma might want addressee and eight hydro dr synchronous i twenty four hour was one
0:01:09week and four weeks of age
0:01:12this was the prospect to double blind randomised controlled trial hellfire inspection of three specific
0:01:18oxygen concentrations of twenty one percent forty percent or hundred percent oxygen add or maybe
0:01:25inference less than thirty two weeks gestation
0:01:28but we apply what to concentration and the st want to recordings or blinded initially
0:01:33and i don't master ten minutes of age
0:01:36they could involve only at penn's doing this study because of the implementation of twenty
0:01:42ten and not be guidelines
0:01:45and not be upper and lower saturation limits are superimposed on the is you two
0:01:50curves of that the oxygen resuscitated groups
0:01:54that's elicitation of premature infants with hundred percent or two i shown in red resulted
0:01:59in sp with two values
0:02:01about the upper limit of the twenty ten guidelines in the first ten minutes after
0:02:06about
0:02:07the forty percent or two resuscitated group actually in blue and sp modal values below
0:02:13the and not be lower limit in the first five minutes and within the range
0:02:17by six to ten minutes of age
0:02:20so only twenty one percent or two necessitated group actual by the green line had
0:02:25made dispute two values about the and not be lower limit in the first five
0:02:30minutes and between the and not be defined sp would to target range from six
0:02:35to ten minutes
0:02:37however our numbers were small too many humid definite conclusions
0:02:44despite underestimating and final to was significantly higher in one hundred percent or to group
0:02:50the maintain the target s being able to i'm to thirty minutes of age
0:02:55there was no significant difference in f five o two between
0:02:59forty percent or two and ninety one percent or two groups doing the printing presses
0:03:03genocide reassessed initial was significantly more a twenty four hours
0:03:10the hundred percent or to group compared with twenty one percent or two and for
0:03:14the person or two groups
0:03:16suggesting higher ox the data stress in this group
0:03:20the rationale was not different among the groups i one week on it for weeks
0:03:24of age plasma vector patterson in one curve approximated formation was higher in the two
0:03:30oxygen necessitated groups over time
0:03:33also hundred percent or to group had higher might have assumed compared to the other
0:03:38two groups i twenty four hours
0:03:41it would be a signal on the same labels were similar a twenty four hours
0:03:45and it for weeks among the groups
0:03:47however i do a dog levels were significantly higher act four weeks come back to
0:03:53twenty four hours among the groups
0:03:55to control you have defined the natural evolution of sp work to in the first
0:04:00and the names of life bit exposure to three different concentrations of oxygen
0:04:05randomization to higher f i o to lead to higher total oxygen exposure address elicitation
0:04:11and this was significantly correlated but markers a system of oxygen stress
0:04:18all that wonderful studies have i missed issues in mormon oxygen at resuscitation the novelty
0:04:25of our study was in key the oxygen concentrations constant at resuscitation thank you