0:00:00living vol normalization and block problem as an aspect on a medicine
0:00:04send the budget a fortune
0:00:07living normalization is an amazing the useful technique to more than on a condensed video
0:00:10as we speak leaning of evolution within it is no well and multi month
0:00:15you discoveries and made regarding better dog transportation and effectiveness against and dr counts as
0:00:19multi drug resistant counts as it was first proposed in nineteen thirty six by one
0:00:24columns likely hypothesized that it will be possible to use in you feel like let
0:00:28donating initiator the start and the simple normalization reaction that has no change transfer or
0:00:33termination steps
0:00:34but it wasn't until nineteen fifty six am and called michael's rock
0:00:38and coworkers to prove that it was possible
0:00:41now the idea when you can file a lengthened only to attacking a common the
0:00:45robot is a bit harder except singers you're trying to add an electron for node
0:00:49electron which upon for example for the video now i gotta by packet objective screen
0:00:54crack is that you one of the people who always keep jacob screen packets handy
0:00:57by a pc congratulations the data's finally paid off gotten good
0:01:01now pose a video again anyhow them without any what to do not good you're
0:01:06now modeling electron which can cover the one with the crackers in your mouth
0:01:10not when a to have the back at heart go
0:01:13now if yes did that i showed you be a willingness to make a pretty
0:01:16bizarre besides it does not do that than i disapprove your lack of commitment
0:01:20but you able to imagine outcome
0:01:23so how do which read and you can file that it is a good idea
0:01:25to attack i like from which column common upper bound by having about the electron
0:01:29withdrawn group attached to want this makes the robot lesser electron which are more susceptible
0:01:34to attack menu could well imagine if you will the state of mind your enough
0:01:37for a night out of colours for the cognitive functions on your stumbling home when
0:01:41you spike about that
0:01:42the user you would look twenty said that but effective our goal make idea like
0:01:46about much more p c except i make use of a disastrous times action and
0:01:50will quickly feature doing talk about
0:01:53in is rather tenuous analogy the alcohol of sense the electron withdrew group and shows
0:01:57how this extra incentive allows and you could default attack the problem once monday telecom
0:02:02by nine common the minus jobs close to stabilize by the electron withdrew if it
0:02:06is a minus and e g n s to accomplish the gas
0:02:09through the use of resonance forms so the minus charges petticoats a larger area "'cause"
0:02:14you all other to build able charge of a bad thing
0:02:17this can be likened repeated toasted mom i don
0:02:19did you like me like small my small quantities which probably makes me in the
0:02:22my noisy but alarm of anyway imagine two nice crunchy slice to boundaries marked on
0:02:27one of them received all of them all my line one corner
0:02:30with the best to that was better but this morning breakfast whereas the other is
0:02:34then is better than a match the entire slice it covered much better
0:02:38this is what the monies and we've does helps but the mom again election density
0:02:41across a large area making much more the least mean stable i don't on we
0:02:46now
0:02:48i
0:03:08welcome back
0:03:11seven
0:03:12this is the initiation stable and ironically length normalization
0:03:15and implement remember this step it happens very fasting about the next
0:03:20so every molecule of the initiator climate changes formed with the living and
0:03:25the combine and come with a month jobs
0:03:28based and propagates to basically the same reaction the car and actions in your file
0:03:32unbounded another common type of and i'm use the living calvins the end of a
0:03:36molecule now let's reaction goes of a particular rate thus because of upon a change
0:03:41are created basically the same time the change go at the same weight so the
0:03:44climate change a whole a very similar molecular weight and lands
0:03:47that are very low value for that politics pasty using this campus can design a
0:03:51problem that make it find amount of it and austria to make it in exactly
0:03:56so you have no point one most of the initiator that means you will end
0:03:59up with no point one of the problem
0:04:01and if you and one more than one but no point one models of the
0:04:04initiator you'll get a problem of that is one of an open one equals ten
0:04:08would but as long
0:04:09what's even more useful is that after all the model is used at the living
0:04:13and its dual reactive see get more them on "'em" and it will continue going
0:04:16or you got a different one am i create block open this with the fine
0:04:20blocks of different one in this decided to mix and match properties with the different
0:04:25blocks within the problem
0:04:27basically is likes nancy engineering taking the best to do things combining them except that
0:04:31the whole corpus using
0:04:33and it sounds the unequivocal amount of your time is used as fast as a
0:04:55one extremely useful application of block co polymers is using them in an image scene
0:04:59and what the most promising of all block upon that is
0:05:01optional one explore probably accents
0:05:04these are made up of high the phonetic want to loving polyethylene oxide p o
0:05:09and height of public would hating probably not side p o blocks arranged in an
0:05:13may be eight five block structure p o p o p o
0:05:19this makes a block open on a were designed with the like after that and
0:05:22height of folks and can't like animals code i don't have jam hide refer back
0:05:27some effort into twenty biscuits
0:05:29i just like okay i think i'm taking this analogy thing a bit too far
0:05:33these co problem as a phallic both height of like and height of vocalic so
0:05:37they have a lot of instinct properties chiefly the ability to interact with side effects
0:05:40the substances and biological membranes
0:05:44this makes this problem is amazingly useful for transportation applied for drugs within the body
0:05:48this it's even the concentration of the co problem lies above the critical missed illes
0:05:53concentration c and c i was point upon the sofa symbols into a bowl six
0:05:58structure with the height of the like and spacing outwards the height of a weekend
0:06:02spacing image
0:06:03towards this end in simple terms this create a trojan horse in which you can
0:06:06store what insoluble drugs
0:06:09the piano shell has added bonus of keeping the drug in a dispersed state rate
0:06:13is less like to have unwanted interaction fit normal cells and protein and have any
0:06:17ability to kind of the hidden drug across the intestinal border and the blood train
0:06:21that
0:06:22also it turns out the not only these amazing trojan horses a lot of the
0:06:26transport of what enjoyable drugs into the can sell but they also make and the
0:06:30occurrences
0:06:31more sensitive to the drugs to a number of different steps
0:06:34it sends the micro viscosity of the membrane to become so the course of the
0:06:37at p and then design five phosphate levels to decrease which basically stopped energy being
0:06:42transported on the cell
0:06:44it even goes as far suppressing the consoles drug a an influx system its ability
0:06:48to throw out unwanted rocks but it turns out of these effects are more prevalent
0:06:52in the non ms l is the weather but is another problem so the doing
0:06:57them is more effective at making a cell more sensitive
0:07:00i think the in them as the assassins it's needing to the city of troy
0:07:02and motorola gods and the cities with the classic trojan horse but what i hear
0:07:07you cried is amazingly tactical minded chemical not attack healthy cells
0:07:12well it is it does
0:07:14a bit that it is more likely to attack cancer cells by the enhanced coming
0:07:18ability "'em" attention
0:07:20e d affect which isn't really relevant this presentation another cutting is application or opera
0:07:25one x is actually spacing damage sounds usually one thousand damage that's it you try
0:07:29and data cells you can and limited times but the research is backed by l
0:07:33t and k u e this might you change
0:07:36basically what scores so that is holes in the membrane the membrane regulate what close
0:07:41enough to sell keeping will because of and all that stuff
0:07:44but one house their disability second and the active diffusion means that the inside the
0:07:48cell diffuse out an outside if uses in
0:07:51selled s
0:07:52but is plaques no one eight you can plug the holes
0:07:55of course this plot won't be able to act as the possibly fit and poking
0:07:59membrane and that's the transport system and the cell but it will stop the active
0:08:04diffusion from coding so that
0:08:05among the tent the campus is the number in a cell and allows a and
0:08:09then a document can survive but keeps the water out so there you go occupant
0:08:13uncomfortable when the membrane campus gets holes in it was not in an open to
0:08:17get a wet
0:08:18but if you pass of the data plastic square as well a normal rain in
0:08:23yes the processing that i mean
0:08:25but the rest the compass told us
0:08:27this is the quick look at the limitless possibilities a wife combine on the chemistry
0:08:31within a time but is no chemistry
0:08:34thank you for watching
0:08:35i o