| 0:00:00 | my name is of course one and i prefer sort of buttons that might be |
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| 0:00:05 | university |
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| 0:00:06 | and then the end of the buttons and department and hypertension unit in the fine |
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| 0:00:12 | she with the considered dimensional is one |
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| 0:00:15 | and i'm working with melatonin for the last eight use of cleanliness not affect a |
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| 0:00:23 | lot question before we start what does without the effects i would like to give |
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| 0:00:27 | some in production model up we show i potential is one of the major risk |
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| 0:00:32 | factors for called of a small |
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| 0:00:34 | movement in modality and we know that not where shows some still could be an |
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| 0:00:40 | pattern it usually goes down during the nighttime |
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| 0:00:45 | and this pattern we call is called deep in butter |
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| 0:00:50 | and in those patients so the laplacian l does not go down during the night |
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| 0:00:56 | we talk about one db |
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| 0:00:59 | and we know that these patients had higher cardiovascular voice |
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| 0:01:05 | now we don't know why some variations out on the rails |
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| 0:01:09 | but we know that one of the on one |
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| 0:01:12 | that is responsible for falling asleep is reluctantly |
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| 0:01:17 | but not only in is a more likely that was used by the united of |
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| 0:01:21 | and that night |
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| 0:01:22 | and it serves as the signal out for darkness in the organisation and the times |
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| 0:01:29 | you for the biological clock |
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| 0:01:32 | in the bright |
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| 0:01:34 | no few years ago |
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| 0:01:37 | wavefile that known deep as short less |
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| 0:01:42 | off included in the log domain during nighttime this was probably used in lap ratio |
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| 0:01:49 | eight years |
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| 0:01:51 | seriously so that a lot on mean does not go up doing tonight i mean |
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| 0:01:57 | on because we try to three |
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| 0:02:01 | variations but not too not hypertension we reluctantly |
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| 0:02:06 | and we well very successful |
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| 0:02:09 | and showed |
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| 0:02:11 | that but not only at night |
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| 0:02:13 | can be can is |
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| 0:02:15 | not to will not laplacian |
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| 0:02:17 | this was published to all six |
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| 0:02:20 | in the market module out of this |
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| 0:02:24 | since then that well some additional studies |
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| 0:02:29 | we not consistent results some stuff this confirms our observation that's melatonin can follow a |
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| 0:02:37 | laplacian at night |
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| 0:02:39 | but are does show no effect |
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| 0:02:43 | therefore with the side the to collect all the information |
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| 0:02:48 | available in the literature do a matter how does it is to show |
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| 0:02:54 | what are the real effect of reluctantly |
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| 0:02:58 | i will add darpa's was not only to see what is the effect but also |
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| 0:03:03 | see that the is different effects of fast |
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| 0:03:08 | and control willies reluctantly |
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| 0:03:12 | if the onset of n |
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| 0:03:14 | papers |
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| 0:03:15 | including two hundred and twenty one patients |
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| 0:03:19 | that well published |
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| 0:03:22 | and when we define the that |
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| 0:03:24 | studies and two dollars |
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| 0:03:26 | we use faster is not only |
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| 0:03:29 | and those labels controller |
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| 0:03:32 | we'll have that |
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| 0:03:34 | only control and is relatively |
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| 0:03:37 | decrease significantly |
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| 0:03:40 | and not to learn how do not show well as the fast lately and no |
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| 0:03:45 | effect |
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| 0:03:46 | so we believe that the addition of control but lately is will apply |
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| 0:03:52 | two and t i intensive treatment |
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| 0:03:55 | p l o l not to on the laplacian |
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| 0:03:59 | if this is the case then this is mainly due significantly cardiovascular ability and modality |
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